Organic Chemistry and its applications
.::. Invited Lecture
1
34
EFFICIENT MECHANO CHEMICAL GREEN SYNTHESIS OF HETEROCYCLES [ATOM ECONOMY-YIELD ECONOMY AS METRICS OF SYNTHETIC REACTIONS EFFICIENCY]
Amin F. Fahmy , Sameh A .Rizk , Amira A. El-Sayed , Magdy M. Hemdanand , Aya I. Hassaballah
Faculty of Science, Department of Chemistry, Ain Shams University, Abbassia, Cairo, Egypt
Faculty of Science, Department of Chemistry, Ain Shams University, Abbassia, Cairo, Egypt
Faculty of Science, Department of Chemistry, Ain Shams University, Abbassia, Cairo, Egypt
Faculty of Science, Department of Chemistry, Ain Shams University, Abbassia, Cairo, Egypt
Faculty of Science, Department of Chemistry, Ain Shams University, Abbassia, Cairo, Egypt
ABSTRACT
The role of chemists is essential in ensuring that our next generation of chemicals, materials, and energy is more sustainable than the current generation. One of the most attractive concepts in chemistry for sustainability is Green Chemistry, which is the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture, and uses of chemical products. One of the key aspects of Green Chemistry is the elimination of solvents in chemical processes. Multi-component reactions [MCRs] enable fast production of heterocycles in a single operation and thus respect the demanding eco-compatibility principle like step efficiency and atom economy. On the other hand Mechano heterocyclic chemistry (MCHC) is a recent quickly growing technique in the synthesis of heterocycles and draws the attention of heterocyclic chemists towards the uses of the grindstone technique in a solvent-free green efficient synthesis of many heterocyclic systems. The key advantages of this strategy, over conventional approach, include its simple, solvent-free conditions, as well as its facile work-up, high atom economy [AE] and high yield economy [YE]. We use Grinding in both one-pot multistep and Multicomponent strategies for sustainable green synthesis of a wide range of condensed, noncondensed five, six, and seven-membered heterocyclic systems, some of them showed insecticidal or biological activities...
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
2
34
Coumamarin: a first coumarinyl calcium complex isolated from nature
Abdelaaty Hamed , Ahmed S. Abdel-Razek , Marcel Frese , Hans Georg Stammler , Norbert Sewald
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt
Microbial Chemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, El-Buhouth St. 33, Dokki-Giza 12622, Egypt
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, 33501 Bielefeld, Germany
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, El-Buhouth St. 33, Dokki-Cairo 12622, Egypt
ABSTRACT
The first calcium complex from nature, Coumamarin (1), 7-hydroxy-3-methoxy-2-oxo-2H-chromene-6-carboxylate Ca(II) complex, was isolated from Aspergillus sydowii ASTI, together with diorcinol (2), violaceol I (3), hydroxysydonic acid (4), cyclo (Trp-Phe), kojic acid, ergosterol, and uracil. The producing strain was isolated from marine water sample collected from Tiran Island, Red Sea, Egypt. Structure 1 was assigned by intensive 1D, 2D NMR, HR-ESIMS, and X-ray crystallography as well. Coumamarin is potentially active against certain tested bacteria and yeasts, while showing no cytotoxic activity against human cervix carcinoma cell line (KB-3-1). Taxonomically, the fungus was identified by phylogenetic analysis of its 18S rRNA gene sequence.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
3
34
Mn (II) and Pd (II) complexes of azine Schiff-base ligand: Synthesis, molecular structure, thermodynamic parameters, surface activity and docking studies of DHFR enzyme
I.A. Ibrahem , E. F. Abo Zeid
Chemistry Department, Faculty of Science, Al Azhar University, Nasr City, Cairo, 11884, Egypt
Physics Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
ABSTRACT
In the present work, the complexes of orthohydroxyacetophenone azine ligand with Mn (II) and Pd (II) ions was prepared and characterized by different physicochemical techniques. The identification methods include Infrared-spectroscopy, magnetic moment, electronic spectra, X-ray powder diffraction, scanning electron microscopy and thermal analysis. From the data of the prepared complexes, the orthohydroxyacetophenone azine ligand chelates acts as a bi -dentate via oxygen and nitrogen atoms of imine and phenolic groups, respectively. Electronic spectra, magnetic properties and electronic spin resonance of the prepared samples indicate that it has an octahedral and square planar geometric structure for Mn(II) and Pd (II) complexes, respectively. The number, nature, and locations of water molecules are discussed through the results of thermal analysis, which confirms the presence of two coordinated water molecules. From the thermodynamic values, the high values of the activation energies reflect the highly thermal stability of the prepared complex and the negative values of the entropy of activation indicate that the decomposition reactions proceed with a lower rate than the normal ones. The SEM micrographs of metal complex shows an elongated and highly dispersed particles that form large agglomerates in which narrow distributed particles are uniformly distributed in the crystalline lattice of the ligand. Docking was performed for the ligand and its complexes with Mn(II) and Pd(II) ions on the dihydrofolate reductase (DHFR) in a trial to predict their mode of action as anticancer drugs. Docking studies show the high activity of the palladium complex compared to the manganese complex. This behavior complex confirmed by the highly active surface area of Pd (II) complex which obtained from the XRD data.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
4
34
Synthesis, Identification and Pharmacological Evaluation of Some Heterocycles Containing Fluorine as Potential Anticancer Agents
Yousry A. Ammar , Eman A. Fayed , Ashraf H. Bayoumi3 , Nervana A. Gohar
Organic Chemistry Department, Faculty of science (Boys), Al-Azhar University
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University
ABSTRACT
Cancer, along with cardiovascular diseases is the major contributors to mortality rates globally. Out of these two, cancer is expected to be the single controlling factor for life expectancy worldwide in the 21st century. Approximately, 18.1 million new cancer cases were expected in 2018 which affected about 9.6 million lives all over the world. This leads us to synthesis new heterocyclic compounds with promising anticancer activities. The first theme of the present study is directed towards synthesis of pyrazolo[1,5-a]pyrimidines. The second theme is to study their biological properties as anticancer agents. 5-Amino-3-hydroxy-4-(3-trifluoromethylphenyldiazenyl)-1H-pyrazole was used as a starting scaffold for the synthesis of new Pyrazole-based heterocycles to study their effects on the proliferation of three human cancer cell lines; human liver carcinoma cell line (HepG-2), colon cancer cell line (HCT-116) and human breast cancer cell line (MCF-7) by MTT assay. The synthesized compounds were characterized on the basis of IR, 1H NMR, 13C NMR, mass spectral data, and elemental analysis results. Cytotoxicity assay results revealed that compound 3a was found to be approximately equipotent of activity to the reference standard with (IC50 = 4.69, 7.73 μg/mL) against HepG-2 and MCF-7 respectively, while showed one third of activity of Imatinib against HCT-116 with (IC50 = 4.69 μg/mL). It was also observed that pyrazolo[1,5-a]pyrimidine-6-carbonitrile 10b was the most potent anticancer agent, it showed 9th fold of activity of Imatinib against HepG-2, 1.5 fold of activity of Imatinib against HCT-116 and about three fold of activity of Imatinib against MCF-7. At the same time compound 11a showed promising cytotoxic activity; nearly 0.75, of activity of the reference standard against HepG-2, half of activity of the reference standard against MCF-7 and 1/6 time of activity of Imatinib against HCT-116 (IC50 = 8.47, 11.2 and 12 μg/mL) respectively. In addition 3D pharmacophore model was generated to explore the structural requirements controlling the observed cytotoxic properties.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
5
34
Multifunction paint based on new modified polyesteramide resin as a binder for industrial applications
H. Abd El-Wahab , Abdelhalim Mustafa , Said Ahmed , Ahmed Mohamed
Professor of applied organic chemistry
Professor of organic chemistry
Researcher
Demonstrator
ABSTRACT
New modified polyesteramide compositions were prepared and evaluated as a binder for multifunction paint , the prepared new binder was prepared by partial replacement the sorce of polyol using 4-amino -N ,N-bis (2-hydroxyethyl) benzamide as a modifiers which carried out by solvent technique, the prepared modifiers and modified binder were confirmed by different analysis acid value, FT-IR, HNMR MW and SEM. The resins were incorporated within primer formulation and evaluated as a fire retardand, anticorrosive and antimicrobial paint . The coatings of 50±5 µm thickness were applied to the surface of glass panels, wood substrate and mild steel strips by means of a brush. The coating performance of the resins was evaluated using international standard test methods and involved the measurement of phyisco-mechanical properties. The results illustrate that the introduction of 4-amino -N ,N-bis (2-hydroxyethyl) benzamide as a modifiers, within the resin structure, improved the film performance and enhances the fire retardant, antimicrobial and corrosion resistance.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
6
34
Effect of different acceptors on N-hexyl carbazole dyes for Dye-Sensitized Solar Cells: Synthesis, Characterization, Molecular structure and DSSC fabrications.
Yousry A. Ammar , M. A. Abu-Saied , Marwa Fathy , Ahmed A. El-Sherif , A. B. Kashyout
Organic Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt.
Electronic Materials Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt.
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Electronic Materials Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria 21934, Egypt.
Organic Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
ABSTRACT
Carbazoles are one of the more common dye scaffolds for dye-sensitized solar cells (DSSCs). In order to extension novel carbazole dyes, three organic dyes DRA-HC, DCA-HC and DTC-HC which contain hexyl moiety as electron donor and cyanoacetic acid, rhodanine-3-acetic acid and tetracyanoethylene as an electron acceptor, connected by carbazole unit have been reported for dye-sensitized solar cells (DSSCs). Explorations on the relationship between the dye structures, photophysical / electrochemical properties, molecular structure and DSSC fabrications have been described. All the structures showed more positive ground state oxidation potential than the redox potential of I- / I-3 electrolyte and more negative excited state oxidation potential than the conduction band edge of the semiconductor. The DSSC device with DCA-HC displayed high power conversion efficiency (η = 1.41 %) compared to the others with an open circuit voltage (VOC) of 708 mV, short circuit current density (JSC)
of 2.45 mA / cm2 and fill factor (ff) of 0.81 under simulated AM 1.5G irradiation (100 mW/cm2).
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
7
34
Reactivity of Copper (ll) complex with pyrano[2,3-c] pyrazoles derivatives towards biomimetic catalysts for oxidative pyrogallol and optical bandgap.
Mohamed M. Al-Sayed1, , Ibraheem O. Alia2, , Karam S. El-Nassera2, , T.A. Taha3, , E. S. Gad2
1- Chemistry Department, Faculty of Science & Arts Al-Mukhwah, Al-Baha University, Al-Baha, Saudi Arabia
2- Chemistry Department, College of Science and Arts, jouf University, P.O. Box 756, Al-Gurayyat, Saudi Arabia
3- Physics Department, College of Science and Arts, Jouf University, P.O. Box 756, Al-Gurayyat, Saudi Arabia
ABSTRACT
Pyrano[2,3-c]pyrazole (AMPC) ligand prepared and characterization. new copper complex CuIIAMPC was characterized by different tools. The mode of metal-binding shows that the copper binds with the ligand through the nitrogen atoms of the amino and cyanide groups. The copper complex has been used in homogenous oxidation of pyrogallol in the presence of a green oxidant H2O2. values of the kinetic parameters were obtained Km = 17.1mM, kcat= 0.0089S-1 and kcat/Km = 0.523 M-1S-1. The optical energy band gap of indirect E_g2^opt and direct E_g1^opttransition and Urbach energy EU were obtained. Density functional theory (B3LYP-6-31G(d)) was performed to study the effect on understanding the interaction mode of the complex with zeolite. The QSPR was calculated depending on: optimization geometries, frontier molecular orbitals (FMOs), thermodynamic parameters, global and local chemical reactivities, dual, multi and group publicity were discussed for synthesized compounds, using DFT\B3LYP with 6- 31G* level of theory. The molecular electrostatic potentials (MEPs) were plotted to elucidation an interaction manner of synthesized compounds with the receptor. The NLOs manners were elucidated via 1st and 2nd hyperpolarizabilities. The charge transport mechanism was predicted based on ionization optional (IP) and bond dissociation enthalpy (BDE), which used for investigation autoxidation properties.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
8
34
Solid State Study for Barbituric Acid and Uracil Thorium Complexes
Mamdouh S. Masoud , Hesham M. Kamel , Mohamed H. ElSaiefy
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
Medical Laboratory Technology Department, Faculty of Allied Medical Sciences, Pharos University, Alexandria, Egypt
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
ABSTRACT
Syntheses of barbituric acid and uracil Th complexes have been reported. Elemental analysis of the prepared metal complexes, structural investigation of the complexes to know their geometries and mode of bonding based on: Infrared, electronic spectra, dielectric measurements and magnetic susceptibility were studied. The thermal behavior of Th(BA)2 complex has been studied applying differential scanning calorimetry (DSC). Thermodynamic parameters, decompositions and thermal stabilities are calculated and explained. Some theoretical studies were carried out to obtain the charges, bond lengths, bond angles, and dihedral angles of the studied ligands, where the chemical potential, electronegativity, hardness and softness are determined, using hyperchem program. Molecular modeling of the ligands was performed using PC computer to give extra spot lights on the bonding properties of these compounds.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
9
34
New Hydrazones Bearing Morpholinosulfonyquinoxalines Scaffold: Synthesis, Characterization and Antimicrobial Investigation
Yousry A. Ammar , Awatef A. Farag , Abeer M. Ali , Ahmed A. Askar , Doaa M. Elsisi
Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Botany and Microbiology, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
ABSTRACT
2-Hydrazino-6-morpholinosulfonylquinoxaline-3-dione (2) was prepared and used as a starting material in the synthesis of different huydrazone deerivatives. Thus, condensation of compound 2 with some carbonyl compounds afforded the corresponding hydrazone derivatives 3-10. In addition, the corresponding thiosemicarbazide derivative 11 was obtained through the reaction of compound 2 with phenyl isothiocyanate. Furthermore, interaction of the hydrazide derivative 2 with succinic anhydride furnished the acid hydrazide derivative 12. Interaction of compound 2 with acetylacetone and ethyl acetoacetate for obtaining pyrazole derivative but instead the corresponding hydrazone derivatives 13 and 14 were obtained. On the other hand, the cyano pyrazole derivatives 15 and 16 were obtained via the reaction of huydrazino derivative 2 with the cyano arylidene derivatives. The structures of the newly synthesized compounds were confirmed by spectroscopy (IR, 1H, 13C NMR, MS) and elemental analysis. All the synthesized compounds were evaluated for in vitro antimicrobial potential against various bacteria and fungi that showed considerable antimicrobial activity against tested microorganisms.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
10
34
Synthesis and Antimicrobial Evaluation of Some New Annulated Pyrrolidine, Imidazole, 1,2,4-Triazole and Quinazolinone Derivatives
Sawsan A Fouad
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
ABSTRACT
Cyanothioformamide derivative 2 was used as starting material for the synthesis of substituted heterocycles such as pyrrolidine, imidazolidine, 1,2,4- triazole and quinazolinone derivatives. The structures of the obtained products were established based on spectroscopic IR, 1H NMR, MS and elemental analyses. The activity of these products as antibacterial and antifungal agents was studied to through some light on structural activity relationship. Some of synthesized compounds showed significant antibacterial and antifungal activities.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
11
34
Design, Synthesis and Molecular Docking of a Novel Series of Heterocyclic Compounds Bearing Pyrazole Moiety as Potential Anti-Inflammatory Agents
Eman S. Nossier , Somaia S. Abd El-Karim , Hanaa S. Mohamed
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Research Division,National Research Centre, Dokki, Giza, Egypt
Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Research Division,National Research Centre, Dokki, Giza, Egypt
ABSTRACT
With the aim of developing novel anti-inflammatory scaffolds, a new series of pyrazole-substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized through different chemical reactions and validated by means of spectral and elemental data. The new obtained compounds were investigated for their anti-inflammatory activity using the carrageenan-induced paw edema standard technique and revealed that, compound 8 showed increased potency with % inhibition of edema -98.16 ± 1.92, higher than the standard reference drugs diclofenac, indomethacin and celebrex (-73.86, -86.13 and -83.76 %). Molecular docking simulation was initiated herein to validate the attained pharmacological data and provide understandable evidence for the observed anti-inflammatory behavior.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
12
34
Quinoline-Thiazole Conjugates: Searching for Anticancer Agents, Facile Synthesis and Pharmacological Evaluation
Sadia A. Hussein , Abeer M. Ali , Ahmed Ragab , Sonds Mohamed , Ahmed B.M.Mehany
Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo,Egypt
Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo,Egypt
ABSTRACT
A series of quinoline incorporated thiazole derivatives were efficiently synthesized starting with 2-chloro-7-ethoxy-3-formylquinoline. Thus, condensation of this compound with thiosemicar-bazide derivatives afforded the corresponding thiosemicarbazones. Many thiazole derivatives were obtained through the cyclization reaction of thisemicarbazone derivatives with different reagent. Fifteen compounds of the prepared compounds were evaluated against three cell lines. The synthesized compounds were characterized on the basic of spectra (FT-IR, 1H-NMR, 13C-NMR) analysis. Subsequently, the compounds were examined for in vitro cytotoxic effects on three cell. These compounds showed moderate to good and some compounds were observed to be less than doxorubicin (stander drug). More importantly, they were non cytotoxic against wish cell non tumor derived cell lines.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
13
34
Synthesis of new organic dyes containing dicarbazole moiety with different acceptors to improve high efficiency dye sensitized solar cells.
Mohamed R. Selim , Yousry A. Ammar , Gameel A. Elhagali , Moustafa S. Abusaif
Organic Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Organic Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Organic Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Organic Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
ABSTRACT
Dyes applied in dye synthesized solar cells are an important class of organic compounds. In order to extension novel dyes, two organic dyes DRA-BDC and DTA-BDC which contain butyl moieties as a branch and rhodamine-3-acetic acid, thiobarbutiric acid moiety as an electron acceptor, connected by carbazole unit have been studied. We report the synthesis, molecular structures, and Device fabrications on solar cells. Molecular orbital analysis study indicated all dyes can give suitable electron injection from their LUMO orbitals to the TiO2 conduction band. Also, dyes were investigated by UV spectroscopy and cyclic voltammetry (CV). The synthesized dyes were characterized extensively by IR, 1 HNMR, 13CNMR, mass spectroscopy and CHN analysis. Results of Photo physical and electrochemical properties indicated DRA-BDC and DTA-BDC have potential for application in dye sensitized solar cell. The DSSC device with DRA-BDC displayed high power conversion efficiency (η = 0.57%) compared to the others with an open circuit voltage (VOC) of 524 mV, short circuit current density (JSC) of 1.82 mA / cm2 and fill factor (ff) of 0.59 under simulated AM 1.5G irradiation (100 mW/cm2).
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
14
34
Synthesis of Tetrahydroindolocarbazoles and study their applications
Entesar M. Ahmed
Chemistry Department, Faculty of Science, Al Azhar University, Cairo, Egypt
ABSTRACT
Tetrahydroindolocarbazoles with flexible substitutes were developed, determination, characterized structure, then examined for their in vitro
anticancerscreening, evaluated urokinase inhibition, DNA damage was further explored. Compounds 5, 8, 10 and 17 displayed the most promising antitumor activities against the breast cancer cell line as compared to the standard drug, doxorubicin. Compounds 5, 8, 10and 17 represents the most significant urokinase inhibitors of our study respectively.Cell lines treated with 5, 8, 10 and 17 clearly observed a high score of damaged DNA cells. Adeeper examination revealed that our hetroaromatics showed an extensive hydrogen bonding interactions that is required in the S pocket which is important for activity Arg 217, Gly 219, Gly 216, Lys 143 and Ser 190. So we present Tetrahydroindolocarbazoles as promising urokinase inhibitors expected as significant promise for further development as anti-invasiveness drugs.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
15
34
Synthesis and antitumor screening of some novel pyrrolo, pyrrolo[2,3-d]pyrimidinone
and pyrrolo[2,3-b] pyridinone derivatives of sulfaquinoxaline
nashwa mostafa saleh , Sosan A. Fouad , Nadia M. H. Taha , Afaf A .A. Boray
assistance professor
assistance professor
professor
professor
ABSTRACT
The synthesis and screening for antitumor activity of a series of new N4-substituted sulfaquinoxalines
containing moieties such as oxopyrrole, pyrroloacetamides, amino-pyrazolinone, pyrrolo[2,3-d]pyrimidinone
and pyrrolo[2,3-b]pyridinone derivatives are reported. Some of these compounds showed interesting cytotoxic
activities. All newly synthesized compounds were screened as antitumor agents against human tumor colon and
breast cell lines (HCT116 and MCF7) respectively.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
16
34
Synthesis, physicochemical study, biocidal effect and corrosion inhibition of some novel quaternary ammonium salt surfactants containing sulfonate group
Fatma H.abdel-Salam , Nabel A. Negm , Aya E.Hawash
Chemistry Department, Faculty of Science, Al-Azhar University (Girls branch), Youssif Abbas St., Nasr-City, Cairo, Egypt, P.O. Box 11754
Egyptain petroleum research Institute, petrochemical department, cairo,Egypt.
Egyptain petroleum research Institute, petrochemical department, cairo,Egypt.
ABSTRACT
A new type of amphoteric surface-active compounds namely; sodium Salt of 2-Hydroxy -3-(trimethyl azanyl) propoxy -3-(alkanoyl oxy)-1-oxopropane-2-sulfonate were synthesized and their chemical structures confirmed by spectra tools (FT-IR, 1H-NMR and mass spectra). The surface activities of these surfactants were determined using surface tension measurements. Surface tension measurements were used to determine the critical micelle concentration (cmc), the surface tension at the cmc (γcmc), effectiveness (πCMC) and efficiency of adsorption (pC20). It is found that the cmc and γcmc decreased with increasing the hydrocarbon chain length ranged from 14.0 x 10-3 to 3.2 x 10-3 mol / l. The free energy of adsorption is more negative than the free energy of micellization, it is actually easier for surfactant molecules to adsorb on the air–water interface. The prepared surfactants showed good results for antimicrobial properties. Also, the corrosion inhibition was studied and evaluated. The percentage inhibition efficiency increased with increasing the inhibitor concentration. This behavior showed that the prepared surfactants acted as good inhibitors for the corrosion of aluminum in 1M HCl media.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
17
34
Design, Synthesis, Characterization, Pharmacological Evaluation, and Molecular docking study of some new indolin-2-one derivatives
Eman A. Fayed , Yousry A. Ammar , Ashraf H. Bayoumi , Rabab S. Jassas , Rogy R. Ezz Eldin
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University
Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt
Chemistry Department, Al-Jamoum College Umm Al Qura University
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University
Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt
ABSTRACT
Condensation of p-aminoacetohenone with isatin 1 in acetic acid afforded product which was identified as 3-[4-acetylphenyl)imino]indolin-2-one (2). The resulting Schiff base 2b was subjected to react with phenyl hydrazine, thiosemicarbazide or p-anisaldehyde to produce 3-4. On the other hand, aldol condensation of p-aminoacetophenone with isatin in the presence of diethylamine, 3-[2-(4-aminophenyl)-2-oxoethyl]-3-hydroxyindolin-2-one (5) was afforded. Easily dehydration of compound 5 by using hydrochloric acid yielded 3-phenacylidene-2-indolinone (6). Condensation of compounds 5 with salicylaldehyde afforded the corresponding Schiff base 7. The spiropyrazole derivatives 8a, b were obtained when compound 6 was reacted with hydrazine hydrate or phenylhydrazine. Other types of acetyl derivatives reacted with isatin to furnish 9-12. Finally isatin was subjected to react with cyanoacetanilides and the structure of the product was assigned as N-(substitutedphenyl)-2-imino-2H-furo[2,3-b]indole-3-carboxamides (13a, b). Most of the newly synthesized compounds were screened for their anticancer activity against three cell lines which are human breast cancer cell line (MCF-7), human liver carcinoma (HepG-2), and colon cancer cell line (HCT-116). All the tested compounds exhibited antitumor activity with IC50 ranging from 0.76-35.60 μg/mL in a comparison to standard Imatinib. Molecular docking study for most potent compound 8b with active site made a critical hydrogen bond donor via Lys 851 and Asp 831 amino acid residues with a good docking score energy (-19.38 kcal/mol).
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
18
34
Nitrogen-Doped Carbon Quantum Dots embedded Polymer Dots as Metal-free Photocatalysts for Visible-Light-Driven Hydrogen Evolution
Mohamed Hammad Elsayed , Ho-Hsiu Chou
Chemistry Department, faculty of science, Alazhar University, Cairo, Egypt.
Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
ABSTRACT
Carbon quantum dots (CQDs) represent a new class of quantum dots with unique properties. Doping CQDs with heteroatoms provides an attractive means of effectively tuning their intrinsic properties and exploiting new phenomena for advanced applications. Given the photocatalytic properties of semiconducting polymer and carbon quantum dots (CQDs) we report a new structure of metal-free photocatalytic system with a promising efficiency for hydrogen production through combination between organic semiconducting polymer (PFTBTA) and N-doped carbon quantum dots (NCQDs) then covered by PS-PEGCOOH to produce cheap and low toxic heterostructured photocatalysts in form of polymer dots (Pdots). The design of NCQDs and PFTBTA implanted Pdots could provide strong interaction between each other owing to the space confinement effect in the nanometer-sized Pdots. NCQDs is easy to insert inside the Pdot structure and have a compatible energy level with that of PFTBTA which leads to increase the stability of Pdot structure and enhance the hydrogen evolution rate about 6 times higher than pure PFTBTA Pdot.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
19
34
A highly selective turn-on fluorescent probe for monitoring pH and its application in bioimaging of living cells
Mahmoud Basseem I. Mohamed , Tarek S. Aysha , Taha M. Elmorsi , Mervat El-Sedik , Omaima M. Kandil
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt, P.O.11884
Dyeing, Printing and Textile Auxiliaries Department, Textile Research Division, National Research Centre, 33 El Bohouth st, Dokki, Giza, Egypt, P.O.12622
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt, P.O.11884
Dyeing, Printing and Textile Auxiliaries Department, Textile Research Division, National Research Centre, 33 El Bohouth st, Dokki, Giza, Egypt, P.O.12622
Department of Animal Reproduction & A.I., Veterinary Research Division, National Research Centre, 33 El Bohouth St. Dokki, Giza, Egypt, P.O.12622
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt, P.O.11884
ABSTRACT
A new turn on fluorescence probe based on 3',6'-dihydroxy-6-methyl-2-((pyridin-2-ylmethylene)amino)-4-(p-tolyl)spiro[benzo[f]isoindole-1,9'-xanthen]-3(2H)-one (BFFPH) derived from benzo[f]fluorescein was prepared. Full characterization of the prepared probe using spectroscopic analysis was described such as IR, NMR and MS spectra. The sensitivity of BFFPH for monitoring of pH change in the alkaline medium was studied. BFFPH exhibited a high sensitivity to alkaline pH by two pKa values at 8.82 and 10.66 in UV/vis spectroscopy titration. The pH monitoring was studied in a broad range of pH values (2.5-12.2) at two pKa values at 8.72 and 10.73 by recording the effect of pH on the fluorescence intensity of BFFPH. The acid-base reversibility character of the probe was investigated as well as the effect of the pH change on the fluorescence quantum yield. The application of the prepared BFFPH probe for the detection of living Escherichia coli (E. coli) bacteria using a confocal fluorescence microscope was investigated.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
20
34
Synthesis, Anticancer Evaluation and Molecular Docking Studies of New Heterocycles Linked to Sulfonamide Moiety as Novel Human
Topoisomerase Types I and II Poisons
Ahmed H. Halawa , Walid E. Elgammal , Saber M. Hassan , Ahmed H. Hassan , Hesham S. Nassar
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
ABSTRACT
A series of heterocyclic compounds with a sulfonamide moiety were synthesized from reaction of enaminone 4 with active methylene compounds, glycine derivatives, 1,4-benzoquinone, hydroxylamine hydrochloride, hydrazonyl halides and dimethylacetylenedicarboxylate. The newly synthesized sulfonamide derivatives were characterized by FT-IR, 1H-NMR, 13C-NMR, mass spectroscopy, elemental analysis and alternative synthetic routes. The reactions products were evaluated for their antiproliferative activity against a panel of three different human cancerous cell lines, MCF-7 (breast), HepG-2 (liver) and HCT-116 (colon) and the results were deployed to derive the structure-activity relationships (SAR). Various test compounds were potent antiproliferative to cancerous cells; reaching very low micromolar levels, as in case of 21 which showed IC50 value of 6.2μM against HepG-2 cell. In addition, treatment of cancerous cells with the synthesized compounds induced cell apoptosis and G2/M phase arrest evidenced by flow cytometric analysis. Furthermore, the activity of the synthesized compounds against TOP I and II were documented by DNA relaxation assays. Data revealed that compound 24 significantly interfered with TOP I- and II-mediated DNA relaxation, nicking and decatenation, with IC50 values 27.8 and 33.6μM, respectively. Moreover, the molecular docking studies supported the results from enzymatic assays, where compound 24 was intercalated between nucleotides flanking the DNA cleavage site via pi-pi stacking and hydrophobic interactions. In conclusion, aromatic heterocycles linked to sulfonamides are excellent molecular frameworks amenable for optimization as dual TOP I and II poisons to control various human malignancies.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
21
34
Synthesis, Characterization, Anti-cancer screening and molecular docking studies of new thiosemicarbazone derivatives
Ahmed H. Halawa , Walid E. Elgammal , Saber M. Hassan , Hassan Y. Ebrahim , Ahmed B.M. Mehany
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11284, Egypt.
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
ABSTRACT
Reaction of compound (1) with methyl or benzyl hydrazinecarbodithioate (2a,b)
a forded dithioester derivatives (3a,b) which reacted with primary or secondary amines in boiling ethanol furnish the corresponding thiosemicarbazone derivatives 4,5,6,7,9,10,11 and 12 respectively through evolution of methyl or benzyl mercaptan, Also, interaction of Chloroacetic acid ethyl ester on dithioesters 3a,b in dioxane in the presence of triethylamine as catalyst yielded bis(alkylthio) methylene derivative 13 and 14 respectively. All prepared compounds were verified by physico-chemical and spectroscopic techniques. Sulfonamide bearing compounds possess several types of biological activities and have lately been reported to display significant antitumor activity in vitro.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
22
34
Synthesis of a hydrogel by grafting of acrylamide-co-sodium methacrylate onto chitosan for effective adsorption of Fuchsin basic dye
Ahmed Galal Ibrahim , Ahmed Zaky Sayed , Hamada Abd El-Wahab , Mahmoud Mohamed Sayah
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
ABSTRACT
This work was designed to produce effective adsorbent from acrylamide (AAm), sodium methacrylate (SMA) and chitosan (CTS) through free radical grafting polymerization and to use it for removing the Fuchsin basic dye from its solution. Methylene bisacrylamide (MBA) and ammonium persulfate (APS) were used as cross-linker and initiator, respectively. The gel fraction and the grafting parameters were studied as a function of SMA and the results showed that the maximum grafting percentage (1014.3 %) and gel fraction (83.5%) were obtained when the molar ratio of SMA to AAm was 1:1 (the best ratio). In addition, incorporation of SMA into the gel structure enhanced the swelling of the gel by 6.67-9.67 fold as compared with the AAm-graft-CTS gel. FT-IR, TGA, DTG, DTA, and SEM were utilized to investigate the gels. Capacity for the adsorption of Fuchsin basic dye by (AAm-co-SMA)-graft-CTS gel via batch process was tested and the impact of SMA, contact time, agitation rate, gel dose, dye concentration, temperature, and pH was studied. The maximum removal % (97.2%) was achieved at the best ratio, and the adsorption reached the equilibrium at approximately three hours. Best fitting was found by pseudo-second-order kinetic and Freundlich isotherm.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
23
34
Synthesis, Characterization and Biological Screening on some Derivatives of Sulfonamido Phenyl Ethanone
Ahmed H. Halawa , Walid E. Elgammal , Mohamed A. Elnassag , Saber M. Hassan , Ahmed M. Mora
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
ABSTRACT
The utility of 1-[4-((4-methylpiperidin-1-yl) sulfonyl) phenyl] ethanone (1) in the synthesis of some new thiazole, quinoxaline,
benzo[b]thiazine, benzo[b]oxazine, imidazo[1,2-a]pyridine ,imidazo[1,2-a]pyrimidine, imidazo[2,1-b]thiazole, imidazo[2,1-c][1,2,4]triazole, 1,3,4-thiadiazine derivatives pendant to a benzene sulfonamide ring was reported. The structures of the newly synthesized compounds were confirmed by spectral data. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed moderate activities.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
24
34
Preparation and evaluation of new liquid crystal compounds as flow improvers for waxy crude oil
Ashraf M. Ashmawy , El- Sayed M. Elnaggar , Manal G. Mohamed , Mohamed C. Hamam
Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
Petrochemical Department, Egyptian Petroleum Research Institute (EGYPT)
Chemical lab sector, Qarun Petroleum company (EGYPT)
ABSTRACT
The most problem in the petroleum field is the present of paraffinic waxes in crude oil. So, a variety of methods have been utilized to reduce this problem. Flow improvers are usually extensively used to improve the crude oil mobility. Herein, prepared of novel allyl 4-(decyloxy) benzoate I-10, allyl 4-(dodecyloxy) benzoate I-12 and allyl 4-(octadecyloxy) benzoate I-18.These compounds wereccharactrized by spectroscopic and elemental analysis and spectroscopic analyses. The phase transitions were investigated by means of differential scanning calorimetry. The prepared compounds with different concentration were tested as flow improver for Qarun crude oil (QN field) the efficiency increase with the concentration increase. The addition of the high chain compound has the Best flow improvement performance, while the lowest chain has low efficiency.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
25
34
An Efficient Synthesis and Antimicrobial Evaluation of New Phthalazine
Analogous
Ahmed H. Halawa , Essam M. Eliwa , Hesham S. Nassar , Saber M. Hassan , Ahmed M. El-Agrody
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, 11284 Nasr City, Cairo, Egypt
ABSTRACT
A new series of Phthalazine scaffolds (3-25) were synthesized. Hyperidzation with pharmacophoric moieties possessing antimicrobial activity including oxadiazolyl, thiazolyl, pyrimidinyl, and oxadiazinyl-1-oxophthalazin-2(1H)-yl) acetohydrazide was achieved. The obtained compounds were characterized by correct elemental analysis and spectral data (IR, MS, and 1H-NMR). Some of the newly synthesized molecules were tested for their antimicrobial activities. All the compounds that under investigation have moderate activity against all the tested bacterial strains in comparison with the standard drug Ampicillin.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
26
34
Synthesis, Molecular Modeling Studies and ADMET Prediction, of Some Thiazole Containing Heterocycles with Potential Antimicrobial Activity as Inhibitors of Bacterial Peptide Deformylase.
Sally I. Eissa , Amel M. Farrag , Samir Y. Abbas , Mohamed F. El Shehry , Said A. Shedid
Pharmaceutical Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. bFaculty of Pharmacy, Al-Maarefa University for Science and Technology, Riyadh, Kingdom of Saudi Arabia.
Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.
Pesticide Chemistry Department, National Research Centre, Cairo, Egypt.
Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt
Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt
ABSTRACT
One of the best ways to design new biocidal agents is to synthesize hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold. To this end, a new series of quinoline derivatives bearing a thiazole moiety were synthesized. Different substitution patterns were chosen to investigate the difference between each substituent on the effect of the biological activities. The synthesized compounds were evaluated for their expected antimicrobial activity. The minimum inhibitory concentration of these compounds was determined by micro dilution technique using Ampicillin and Gentamycin as reference drugs for Gram-positive and Gram-negative bacteria. Ten test organisms representing two different microbial groups were used: Group 1: (Gram-positive bacteria) Staphylococcus aureus (RCMB 010027), Staphylococcus epidermidis (RCMB 010024), Streptococcus pyogenes (RCMB 010015), Bacillus subtilis (RCMB 010063) and Enterococcus faecalis (RCMB 010068); Group 2: (Gram-negative bacteria) Neisseria gonorrhoeae (RCMB 010076), Proteus vulgaris (RCMB 010085), Klebsiella pneumonia (RCMB 010093), Shigella flexneri (RCMB 0100542) and Pseudomonas aeruginosa (RCMB 010043). Some new derivatives were studied as Peptide deformylase (PDF) enzyme inhibitors, an essential enzyme in bacterial protein synthesis and maturation. Thiazolidin-4-one derivative (3d) and 2, 3-dihydrothiazole derivative (5c) had shown good PDF inhibition activity which had been supported by the docking results with highest binding affinity and lowest docking energy score. Surprisingly, Compounds 3d &5c had also shown significant antimicrobial activity higher than the reference drugs against all the tested strains.
In silico evaluation of ADME properties indicate that all the newly synthesized compounds are orally bioavailable with no permeation to the blood brain barrier. These results suggested that the most potent compounds 3d & 5c might be possible interesting scaffolds for the development of novel bacterial PDF inhibitors.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
27
34
Up-regulation of BAX and Caspase-3, as well as down regulation of Bcl-2 during
indeno[1,2-b]quinoxalin thiazole derivatives, mediated apoptosis in human cancer cells
Yousry A. Ammar , Eman A. Fayed , Amel M. Farrag , Nervana A. Gohar , Ahmed B. M. Mehany
Department of Organic Chemistry, Faculty of Science (Boys), Al-Azhar university, Cairo, Egypt.
bDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
cDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
dDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, MTI University, Cairo, Egypt.
Department of Zoology, Faculty of Science (Boys), Al-Azhar university, Cairo, Egypt.
Department of Organic Chemistry, Faculty of Science (Boys), Al-Azhar university, Cairo, Egypt.
ABSTRACT
In this study, anti-proliferative effects of novel 27 Indeno[1,2-b] quinoxalin-11-one derivatives were investigated in three human cancer cell lines, namely: the colon cancer cell line HCT-116, the liver cancer cell line HepG-2, and the breast cancer cell line MCF-7. Among them, 5, 6, 13, 14a, b and 15d-f derivatives displayed excellent anti-proliferative activities against the three tested cell line compared to the reference standard Imatinib. Therefore they were selected for further studies. First, To ensure the safety of our hits, investigation of the IC50 values on normal human cells (W138) was executed indicating that, they are highly selective (IC50 >107 μM) in their cytotoxic effect. Second, induction of apoptosis by these active compounds was achieved by down-regulation of Bcl-2 and up-regulation of BAX and caspase-3. Further investigations have shown that 14b, the most potent derivative, induced cell cycle arrest at G2/M phase. Moreover, in silico evaluation of ADME properties indicated that all the potent compounds are orally bioavailable with no permeation to the blood brain barrier.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
28
34
Synthesis,Characterization and Thermal Studies of Fe3O4 Nano-particles Coated with Barbituric Acid and their Complex
Prof.Dr. Mamdouh Saad Masoud , Dr. Ahmed Salah El-Din El-Kholany , Dr. Doaa Talha Gebreel
Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Medical Laboratory Technology Department, Faculty of Allied Medical Sciences, Pharos University, Alexandria, Egypt.
Medical Equipment Department, Faculty of Allied Medical Sciences, Pharos University, Alexandria, Egypt.
ABSTRACT
The magnetic nanoparticle (MNP) Fe3O4 that coated with barbituric acid and the complex of (MNP) Fe3O4 with barbituric acid were prepared. The structural, mode of bonding, surface charge, physical size and morphology of the prepared materials were studied by using Fourier transform infrared (FT-IR) spectroscopy, electronic spectroscopy, transmission electron microscopy (TEM), Scanning Electron Microscope (SEM), X-ray diffraction (XRD) and zeta potential.
The mechanisms of the thermal decomposition for the naked Fe3O4 (MNP), Coated NP, prepared complex and the activation energy for the prepared compounds was determined by Broido’s method. Thermal transitions and kinetic studies of the prepared materials were determined by DSC technique.
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10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
29
34
Synthesis, some reactions of some novel Schiffs' bases and their utility as potent antimicrobial agents as well as fire retardants, corrosion inhibitions and for improving drying time of epoxy varnishes
Salwa A. El-Sharabasy , Rafika R.S.Kassab , Nagwa A.El-Hady , Fekria M.A. Soliman , Esraa A.A. Ali
Chemistry Department, Faculty of Science (Girls), Al-Azhar University.
Chemistry Department, Faculty of Science (Girls), Al-Azhar University.
Chemistry Department, Faculty of Science (Girls), Al-Azhar University.
Chemistry Department, Faculty of Science (Girls), Al-Azhar University.
Chemistry Department, Faculty of Science (Girls), Al-Azhar University.
ABSTRACT
A serious novel of Schiffs' bases (IIIa-j) containing the triazole moiety were successfully prepared. The azo methine bridge was alkylated using N-phenyl-3-methylpyrazole-5-one to give (IVa-i). the structures of the newly prepared Schiffs' bases and their alkylated derivatives were elucidated by microanalysis as well as physically by means of IR, 1H-, 13C-NMR and MS measurments. The present study is an attempt to investigate whether the substitution of the various groups can change or improve the potency of the triazole derivatives. They were screened for their reactivity against Gram-positive, Gram-negative as well as fungi and the results were encouraging. Some of the Schiffs' bases were physically inserted into a coating formulations as modifiers and the influence of these modifiers on some properties of epoxy varnish such as drying time of forming films. Likewise, the possibility of using these derivatives as flame retardants and anticorrosive and the results of the study revealed that the incorporation of triazole derivatives have improved drying time of epoxy varnishes and the increasing of modifier percentage is accompanied with decreasing drying times. In addition, adding of modifiers to the epoxy resin has shown impressive results as fire retardants and as the percentage of modifier increased the fire retardance increased. Also, triazole modifiers acted as good steel anticorrosive and as the percentage of modifier increased, the anticorrosive effect increased.
The previous results show that some triazole derivatives possess potent antimicrobial activity and can act as antibacterial agents and using them as modifiers they act as good steel anticorrosives, flame retardants and decreasing the drying time of forming films.
Code
BOT
MATH
STA
CSC
CHEM
GEO
BIO
ASM
PHY
10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
30
34
Utility of admantane1- carbohydrazide in heterocyclic synthesis; Synthesis,characterization and anticancer activity of some new pyrazole derivatives
Y.A.Ammar1, , M M S Wassel , G.A.M.Elhagali1
Chemistry Department, Faculty of Science, Al-Azhar University,
Verterinary serum and vaccine research institute, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University,
ABSTRACT
Pyrazoles carrying adamantly nucleus 4-6, 7, 9a-c were synthesized through the reaction of adamantane -1- carbohydrazide 3 with methylene malononitrile, methylene ethylcyano acetate and ethyl acetoacetate derivatives, respectively. Whereas condensation of ademntane-1-carbohydrazide 3 with either 2-chloro-3-formyl-quinoline or 3-formyl-pyrazole and afforded 11 and 12. Furthermore, heating of 3 with arylhydrazonyl of active methylene and chalcone compounds afforded pyrazoles 13a,b,14 and 15a-c.
Code
BOT
MATH
STA
CSC
CHEM
GEO
BIO
ASM
PHY
10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
31
34
Synthesis and spectral properties of monomethine cyanine dyes based on
pyrido[3,2-e][1,3,4]oxadiazine
Ahmed Zaky Sayed , Fayez Mohamed Eissa , Mohamed Rafat Selim , Mohamed Sharkawi
Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
Chemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
ABSTRACT
Certain cyanine dyes of monomethine type were established incorporating the pyrido [2,3,e]1,3,4-oxadiazine heterocyclic ring system, Firstly the 3-methyl-1H-pyrido[3,2-e][1,3,4]oxadiazine (2) was synthesized via grinding 3-bromo-2-hydroxy pyridine with acetohydrazonic acid (1).
The quaternary salt (3) was synthesized via grinding (2) with excess of iodomethane. Symmetrical monomethine cyanine dyes (5-7) were established via refluxing the quaternary salt (3) with itself, in ethanol and piperidine as a basic catalyst. The quaternary salt of 2-methyl pyrido[2,3-e]1,3,4-oxadiazine moiety attacked another molecules forming the desired monomethine cyanine dyes and this is due to the reactivity of the side chain methyl due to quaternization.
Additionally, the quaternized salt and N-methyl pyridinium, N-methylquinolinium, and N-methyl isoquinoliniumiodide salts (4a-c) in ethanol containing piperidineas basic catalyst afforded the monomethine cyanine dyes (5, 6).
On the other hand, monomethine cyanine dyes (6, 8) were prepared by reacting quaternary compound (2) with N-Methyl (2-picolinium, 4-picolinium, and 4-quinaldinium) iodide salt (7a-c) in ethanol containing pipreridine as basic catalyst.
All the synthesized compounds were purified using glass column chromatography packed with silica and their structures were identified and confirmed by elemental analysis and Mass spectra, 1HNMR, 13CNMR spectral data. The photo sensitization of the prepared cyanine dyes (5, 6, 8) were evaluated via studying their absorption spectral behavior in absolute ethanol giving promising result.
Code
BOT
MATH
STA
CSC
CHEM
GEO
BIO
ASM
PHY
10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
32
34
Synthesis of Some Novel Thiazoles and Coumarins and Study Their Biological Activities
Associate professor organic chemistry, Al-Azhar University, Faculty of science (girls branch), Cairo, Egypt
Associate professor organic chemistry, Benghazi University, Faculty of science, Libya.
M.Sc. in organic chemistry, Benghazi University, Faculty of science, Libya.
ABSTRACT
Abstract: In this article, 5-bromosalicylaldehyde condenses with thiosemicarbazide to afford thiosemicarbazone 2. Reaction of the latter with α-haloester, α-haloketone and/or hydrazonoyl halides afforded thiazoles and thiazolinone 3-6. On the other hand, cyclocondensation of 5-bromo-3-(2-bromoacetyl)-2H-chromen-2-one (7) with thiosemicarbazide gives hydrazinyl thiazole derivative 8 which upon reaction with active methylene compounds or their arylazo derivatives gives pyrazoles 9a,b and 11a-c, respectively. However, reaction of 7 with o-hydroxy aldehydes afforded furan derivatives 12 and 13.
Code
BOT
MATH
STA
CSC
CHEM
GEO
BIO
ASM
PHY
10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
33
34
Antimicrobial evaluation of new thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis and characterization
Yousry A. Ammar , Awatef A. Farag , Abeer M. Ali , Sadia A. Hessein , Ahmed A. Askar
Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Botany and Microbiology, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
ABSTRACT
A series of thiadiazino[5,6-b]quinoxaline and thiazolo[4,5-b]quinoxaline derivatives was designed and synthetized from the reaction of 2,3-dichloro-6-(morpholinosulfonyl)quinoxaline (2) with thiosemicarbazide or thiocarbohydrazide and thiourea derivatives to give nineteen quinoxaline derivatives 3-16. The structures of the newly synthesized compounds were established by spectroscopic data (IR, 1H, 13C NMR, MS) and elemental analyses. All the synthesized compounds were evaluated for antimicrobial potential against various bacteria and fungi that showed considerable antimicrobial activity against tested microorganisms. The most potent compounds 2, 7, 9, 10, 12 and 13c were exhibited bactericidal activity in addition to fungistatic activity by dead live assay. Moreover, these compounds showed a significant result against all multi-drug resistance used especially compound 13c that displayed the best results with MICs of MDRB (1.95, 3.9, 2.6, 3.9 µg/mL) for stains used in this study, compared with norfloxacin (1.25, 0.78, 1.57, 3.13 µg/mL). Also, cytotoxicity on normal cell (Vero cells ATCC CCL-81) by MTT assay was performed with lower toxicity results. Additionally, morphological studies, immunostimulatory potency and DNA gyrase inhibition assay of most active compounds was done. A molecular docking study has also been carried out to support the effective binding of the active compounds at the active site of the target enzyme.
Code
BOT
MATH
STA
CSC
CHEM
GEO
BIO
ASM
PHY
10th International Scientific Conf.
Basic Sciences and its Applications
30 March – 1 April, 2020
Cairo, Egypt
المؤتمر العلمي الدولي العاشر
العلوم الأساسية وتطبيقاتها
2020
ابريل
1
-
مارس
30
القاهرة ـ جمهورية مصر العربية
Organic Chemistry and its applications
34
34
Synthesis, antimicrobial activity and advances in structure-activity relationships (SARS) of novel di-substituted 6-morpholinosulfonylquinoxaline derivatives
Yousry A. Ammar , Awatef A. Farag , Abeer M. Ali , Amany Belal , Ahmed A. Askar
Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Department of Botany and Microbiology, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
ABSTRACT
A series of 2,3-disecondaryaminoquinoxaline derivatives were designed and synthesized via nucleophilic substitution reactions of 2,3-dichloro-6-morpholinosulfonylquinoxaline with various hetrocyclicsecondary amines. The structures of the newly synthesized compounds were confirmed by spectroscopic measurements (IR, 1H, 13C NMR, MS) and elemental analyses. All the synthesized compounds were screened for their antibacterial and antifungal activities. Compounds 7a, 9b, 10a, 10c, 10f and 11c showed high and moderate activity against Gram-positive and Gram-negative bacteria with MIC values ranging from 0.97- 62.5
